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High-altitude exposure duration dependent global and regional gray matter volume decrease in healthy immigrants: a cross-sectional study.
- Source :
-
Acta Radiologica . Feb2023, Vol. 64 Issue 2, p751-759. 9p. - Publication Year :
- 2023
-
Abstract
- Background: The correlation between brain injury and high-altitude (HA) exposure duration (Dur_HA) as well as peripheral oxygen saturation (SpO2) remains unclear. Purpose: To evaluate the global and regional brain volume differences between HA immigrants and sea-level residents, and the relationship between brain volume with Dur_HA and SpO2. Material and Methods: Structural magnetic resonance imaging (MRI) scans were acquired in 33 healthy male HA immigrants (HA group) and 33 matched sea-level male residents (SL group). Differences in global gray matter volume (GMV), white matter volume (WMV), brain parenchyma volume (BV), total intracranial volume (TIV), and the volume-fraction (the ratio of GMV/TIV, WMV/TIV, BV/TIV) were assessed. Regional gray matter differences were investigated using voxel-based morphology analysis. The volume of clusters with GM loss were calculated as the volume of volume of interest (V_VOI). Student's t -test and partial correlation were adopted for statistic calculation. Results: Compared to the SL group, the HA immigrants had larger WMV (P = 0.015), smaller ratio of GMV/WMV (P = 0.022), and regional gray matter loss in bilateral basal ganglion, limbic system, midbrain, and vermis (cluster size >100 voxels, family-wise error corrected at P = 0.01). The global GMV, BV, and V_VOI confined to vermis had negative correlations with the Dur_HA (r = -0.369, P = 0.049; r = -0.380, P = 0.042; and r = −0.471, P = 0.010. Neither global nor regional brain volume correlated with SpO2. Conclusion: Global and regional brain are affected by long-term HA exposure, and global and regional gray matter have a time-dependent volume loss. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02841851
- Volume :
- 64
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Acta Radiologica
- Publication Type :
- Academic Journal
- Accession number :
- 161744067
- Full Text :
- https://doi.org/10.1177/02841851221091674