Exploring the Complex Link between Autophagy, Regulated Cell Death, and Cell Fate Pathways in Cancer Pathogenesis and Therapy.

The authors provide evidence that simvastatin (Simva) enhances temozolomide (TMZ)-induced cell death in GBM cells through UPR-mediated autophagy flux in U251 (p53 mutant) and U87 (p53 wild type) GBM cells. There are three distinct forms of autophagy, including macroautophagy (simply referred to here as autophagy), microautophagy and chaperone-mediated autophagy (CMA) [[1]]. This review highlights four major aspects: key features of pancreatic ductal adenocarcinoma (PDAC), the role of autophagy in tumor metabolism, therapeutic approaches using autophagy inhibitors in PDAC, and autophagy-based strategies to overcome resistance in PDAC. [Extracted from the article]