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Receptors for the third component of complement: their association with maturation stage in non-Hodgkin lymphomas (NHL) and their possible implication with the development of follicular structures.

Authors :
Greil, R.
Gattringer, C.
Schulz, T.
Knapp, W.
Radaskiewicz, T.
Dierich, M. P.
Huber, H.
Source :
Clinical & Experimental Immunology. May1986, Vol. 64 Issue 2, p423-431. 9p.
Publication Year :
1986

Abstract

In the majority of 188 non-Hodgkin lymphomas (NHL) investigated in this study, we found a simultaneous expression of the receptors for c3b and c3d (CR1 & CR2; CCcorr=0.69, P <0.0005). An analysis of the different histological entities of the Kiel classification revealed that this coexpression was most pronounced for germinal center-derived (CCcorr = 0.63, P=0.0004) and immunocytic NHL (CCcorr = 0-86. P=0.0024), whereas in chronic lymphocytic leukaemias there tended to be a more heterogeneotis pattern of complement receptor (CR) expression (CCcorr =0.29, P > 0.10 ) . In contrast to these NHL of mid B cell stage, most of the NHL of early (i.e. acute lymphocytic leukaemia, lymphoblastic NHL) and late B cell stage (i.e. hairy cell leukaemia, immunoblastic NHL, multiple myeloma) did not express either of these receptors. CR positive NHL often showed a follicular arrangement of the neoplastic cells and had higher numbers of T helper/inducer (T4) lymphocytes (PCRI < 0.00005, PCR2 <0.05). Some cases of mid B cell NHL and all cases of hairy cell leukaemia reacted with antibodies against CR3 (i.e. the ic3b receptor). [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00099104
Volume :
64
Issue :
2
Database :
Academic Search Index
Journal :
Clinical & Experimental Immunology
Publication Type :
Academic Journal
Accession number :
16182212