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The challenge of memory destabilisation: From prediction error to prior expectations and biomarkers.
- Source :
-
Brain Research Bulletin . Mar2023, Vol. 194, p100-104. 5p. - Publication Year :
- 2023
-
Abstract
- The re-ignition of memory reconsolidation research sparked by Karim Nader in the early 2000s led to great excitement that 'reconsolidation-based' interventions might be developed for mental health disorders such as post-traumatic stress disorder and substance use disorder. Two decades on, it is clear that reconsolidation-based interventions have been more challenging to translate to the clinic than initially thought. We argue that this challenge could be addressed with a better understanding of how prior expectations interact with information presented in a putative memory reactivation / cue reminder session, and through the identification of non-invasive biomarkers for memory destabilisation that would allow reminder sessions to be 'tuned' to enhance memory lability in an ad hoc manner. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MENTAL illness
*MEMORY
*BIOMARKERS
*POST-traumatic stress disorder
*SUBSTANCE abuse
Subjects
Details
- Language :
- English
- ISSN :
- 03619230
- Volume :
- 194
- Database :
- Academic Search Index
- Journal :
- Brain Research Bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 161904893
- Full Text :
- https://doi.org/10.1016/j.brainresbull.2023.01.010