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Genetics of denatoniumâresponsive bitter receptors in aspirinâexacerbated respiratory disease.
- Source :
-
International Forum of Allergy & Rhinology . Mar2023, Vol. 13 Issue 3, p269-272. 4p. - Publication Year :
- 2023
-
Abstract
- AERD subjects demonstrated increased sensitivity to DB ( I p i < 0.01) and sucrose ( I p i < 0.01) compared with CRSsNP, while CRSsNP subjects demonstrated a reduced sensitivity to DB ( I p i < 0.05) and sucrose ( I p i < 0.05) compared with controls (Figure 1). It was anticipated that in AERD, unique genetic polymorphisms in DB-responsive T2Rs may result in upregulation of the receptors and resulting type-2 inflammation. Keywords: aspirin-exacerbated respiratory disease; bitter; chronic rhinosinusitis; gene; open array; sensory; taste EN aspirin-exacerbated respiratory disease bitter chronic rhinosinusitis gene open array sensory taste 269 272 4 02/21/23 20230301 NES 230301 INTRODUCTION Chronic rhinosinusitis (CRS), a disease of long-standing sinonasal inflammation, is divided into two phenotypes: CRS with and without nasal polyposis (CRSwNP, CRSsNP). [Extracted from the article]
Details
- Language :
- English
- ISSN :
- 20426976
- Volume :
- 13
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- International Forum of Allergy & Rhinology
- Publication Type :
- Academic Journal
- Accession number :
- 161967895
- Full Text :
- https://doi.org/10.1002/alr.23077