Accessibility percolation on Cartesian power graphs.

A fitness landscape is a mapping from a space of discrete genotypes to the real numbers. A path in a fitness landscape is a sequence of genotypes connected by single mutational steps. Such a path is said to be accessible if the fitness values of the genotypes encountered along the path increase monotonically. We study accessible paths on random fitness landscapes of the House-of-Cards type, on which fitness values are independent, identically and continuously distributed random variables. The genotype space is taken to be a Cartesian power graph A L , where L is the number of genetic loci and the allele graph A encodes the possible allelic states and mutational transitions on one locus. The probability of existence of accessible paths between two genotypes at a distance linear in L displays a transition from 0 to a positive value at a threshold β c for the fitness difference between the initial and final genotype. We derive a lower bound on β c for general A and show that this bound is tight for a large class of allele graphs. Our results generalize previous results for accessibility percolation on the biallelic hypercube, and compare favorably to published numerical results for multiallelic Hamming graphs. [ABSTRACT FROM AUTHOR]