Transición de pénfigo vulgar a pénfigo foliáceo. Afección poco frecuente.

BACKGROUND: Pemphigus vulgaris is an autoimmune mucocutaneous disease resulting from the production of antidesmogleins against epidermal desmosomes. These autoantibodies produce blisters by acantholysis. Although pemphigus vulgaris frequently maintains its clinical expression, there is a poorly recognized percentage of patients that present alterations in their autoimmune profile and develop pemphigus foliaceous. CLINICAL CASE: A 25-year-old female patient with a 3-year history of pemphigus vulgaris in remission, who presented plaques with white oily scale on an erythematous base in seborrheic topography. The histopathological diagnosis was pemphigus foliaceus that showed clinical and histopathological transition from pemphigus vulgaris to pemphigus foliaceus. CONCLUSIONS: The clinical transition from pemphigus vulgaris to pemphigus foliaceus is a rare dermatological process of unknown etiology that correlates with the transition of anti-desmoglein 1 to anti-desmoglein 3 autoantibodies. Currently, information on this transition in Latin American patients is limited and highlights the importance of keeping the patient under surveillance. [ABSTRACT FROM AUTHOR]