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Discovery and structure–activity relationships of 2-benzylpyrrolidine-substituted aryloxypropanols as calcium-sensing receptor antagonists
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Feb2005, Vol. 15 Issue 4, p1225-1228. 4p. - Publication Year :
- 2005
-
Abstract
- Abstract: A structure–activity relationship study of the amine portion of the calcilytic compound NPS-2143 resulted in the discovery of substituted 2-benzylpyrrolidines as replacements for the 1,1-dimethyl-2-naphthalen-2-yl-ethylamine. When compared to NPS-2143, a newly discovered compound, 3h, exhibited similar potency as a calcium-sensing receptor (CaR) antagonist and a superior human ether-a-go-go related gene (hERG) profile. [Copyright &y& Elsevier]
- Subjects :
- *VITAMIN D deficiency
*ORGANIC compounds
*VITAMIN deficiency
*OSTEOMALACIA
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 15
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 16203987
- Full Text :
- https://doi.org/10.1016/j.bmcl.2004.11.071