Back to Search
Start Over
α-Internexin immunoreactivity reflects variable neuronal vulnerability in Alzheimer's disease and supports the role of the β-amyloid plaques in inducing neuronal injury
- Source :
-
Neurobiology of Disease . Mar2005, Vol. 18 Issue 2, p286-295. 10p. - Publication Year :
- 2005
-
Abstract
- Abstract: This study investigated the role of α-internexin in the neuronal alterations associated with β-amyloid plaque formation in Alzheimer''s disease (AD). Cortical neurons could be defined by their variable content of neurofilament (NF) triplet and α-internexin proteins, with a distinct population of supragranular pyramidal cells containing α-internexin alone. Both NF triplet and α-internexin were localized to reactive axonal structures in physically damaged neurons in experimental trauma models. Similarly, NF triplet and α-internexin immunoreactive neurites were localized to plaques densely packed with β-amyloid fibrils in preclinical AD cases, indicating that certain plaques may cause structural injury or impediment of local axonal transport. However, α-internexin, and not NF triplet, ring-like reactive neurites were present in end-stage AD cases, indicating the relatively late involvement of neurons that selectively contain α-internexin. These results implicate the expression of specific intermediate filament proteins in a distinct hierarchy of differential neuronal vulnerability to AD. [Copyright &y& Elsevier]
- Subjects :
- *ALZHEIMER'S disease
*NERVOUS system
*NEURONS
*GLYCOPROTEINS
Subjects
Details
- Language :
- English
- ISSN :
- 09699961
- Volume :
- 18
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Neurobiology of Disease
- Publication Type :
- Academic Journal
- Accession number :
- 16206016
- Full Text :
- https://doi.org/10.1016/j.nbd.2004.10.001