Back to Search
Start Over
Effect of beclomethasone dipropionate on nasal metachromatic cell sub-populations.
- Source :
-
Clinical Allergy: Journal of the British Allergy Society . Nov1986, Vol. 16 Issue 6, p589-595. 7p. 1 Chart, 2 Graphs. - Publication Year :
- 1986
-
Abstract
- The effect has been investigated of local administration of beclomethasone dipropionate (BDP) on cell numbers of nasal epithelial metachromatic cell (NMC) sub-populations. Twenty-one patients with perennial allergic rhinitis were studied in four groups according to the duration of treatment or after treatment with BDP. Nasal scrapings were taken after 1 week (Group 1) or 2 weeks (Group 2) of BDP treatment, or after discontinuing BDP for 1 week (Group 3) or 2 weeks (Group 4). Cells were fixed with Mota's lead acetate or 10% buffered formalin followed by toluidine blue staining to count the number of NMC and to classify these according to morphological sub-types (basophils or mast cells). Formalin-sensitive mast cells and basophils in nasal scrapings were reduced more than formalin-resistant mast cells with BDP treatment. Formalin-sensitive mast cells were also more prompt to recover from BDP than formalin-resistant mast cells. The results suggest that the formalin-sensitive NMC is a sub-population of cells which responds to BDP treatment in allergic rhinitis. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BECLOMETHASONE dipropionate
*EPITHELIAL cells
*RHINITIS
*MAST cells
*BASOPHILS
Subjects
Details
- Language :
- English
- ISSN :
- 00099090
- Volume :
- 16
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Clinical Allergy: Journal of the British Allergy Society
- Publication Type :
- Academic Journal
- Accession number :
- 16211141
- Full Text :
- https://doi.org/10.1111/j.1365-2222.1986.tb01998.x