Static magnetic field: A potential tool of controlling stem cells fates for stem cell therapy in osteoporosis.

Osteoporosis is a kind of bone diseases characterized by dynamic imbalance of bone formation and bone absorption, which is prone to fracture, and seriously endangers human health. At present, there is a lack of highly effective drugs for it, and the existing measures all have some side effects. In recent years, mesenchymal stem cell therapy has brought a certain hope for osteoporosis, while shortcomings such as homing difficulty and unstable therapeutic effects limit its application widely. Therefore, it is extremely urgent to find effective and reliable means/drugs for adjuvant stem cell therapy or develop new research techniques. It has been reported that static magnetic fields(SMFs) has a certain alleviating and therapeutic effect on varieties of bone diseases, also promotes the proliferation and osteogenic differentiation of mesenchymal stem cells derived from different tissues to a certain extent. Basing on the above background, this article focuses on the key words "static/constant magnetic field, mesenchymal stem cell, osteoporosis", combined literature and relevant contents were studied to look forward that SMFs has unique advantages in the treatment of osteoporosis with mesenchymal stem cells, which can be used as an application tool to promote the progress of stem cell therapy in clinical application. The brief summary and prospectives of the article. SMFs with different characteristics (intensity and gradient) could synergistically treated osteoporosis by stem cell therapy and underlying mechanisms. SMFs promoted osteogenic differentiation and suppressed adipogenic differentiation of MSCs through a variety of biological mechanisms, such as proliferation, osteogenic differentiation of MSCs, also paracrine effects, autocrine effects and so on. [Display omitted] [ABSTRACT FROM AUTHOR]