Secondary metabolites from marine derived fungus Penicillium chrysogenum Y19-1 with proangiogenic and antithrombotic activities.

Investigation of the ethyl acetate extract from the marine derived fungus Penicillium chrysogenum Y19-1 led to the isolation and identification of nine compounds, including ethyl formyltyrosinate (1), ergosterol peroxide (2), ergosterol (3), cerebroside A (4), conidiogenone C (5), dihydroresorcylide (6), 7-hydroxydihydroresorcylide (7), N-(2-hydroxypropanoyl)-2-aminobenzoic acid amide (8), and 4-methyl-5,6-dihydro-2H-pyran-2-one (9). Their chemical structures were determined by NMR analysis, ESIMS experiment and comparison with the reported data in the literature. Among them, compound 1 was identified as a natural product for the first time. All compounds were evaluated for antithrombotic and proangiogenic activities. Compounds 1 , 4 and 5 exhibited antithrombotic activities, while compounds 1 , 2 , 8 and 9 showed proangiogenic activities. Meanwhile, the chemotaxonomic significance of these isolated compounds was also discussed. • Nine compounds were isolated from Penicillium chrysogenum Y19-1. • Ethyl formyltyrosinate was identified as a natural product for the first time. • All compounds were evaluated for antithrombotic and proangiogenic activities. • Chemotaxonomic significance of these compounds was described. [ABSTRACT FROM AUTHOR]