Special Issue: Yeast Cell Signaling Pathways (Volume 1).

Much has been learnt about the acetyltransferase and deacetylase enzymes that regulate protein-DNA and protein-protein interactions. The ability of acetylation to change protein-membrane interactions and alter the specificity of lipid binding can affect a wide range of cellular processes, including membrane trafficking, signaling, and protein activity. For instance, membrane proteins containing BAR, PX, C2, or EHD membrane-binding domains undergo lysine acetylation in I Drosophila i and they have been implicated in membrane trafficking and remodeling events [[15]]. They provided evidence that the human antimicrobial peptide (AMP) LL-37 triggers cell wall remodeling and the Endoplasmic Reticulum (ER) stress response, which in turn promote oxidative damage, possibly related to changes observed in Ero1-mediated oxidative protein folding, and alterations in protein secretion during I Candida albicans i fungal infection. [Extracted from the article]