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Visualizing ClO− fluxes during homocysteine stress based on a nanoprobe.
- Source :
-
Dyes & Pigments . May2023, Vol. 213, pN.PAG-N.PAG. 1p. - Publication Year :
- 2023
-
Abstract
- As one of important indicators of atherosclerosis (AS), excess homocysteine (Hcy), could cause oxidation stress, thus leading to inflammation and tissue damage. Hypochlorous acid/hypochlorite (HOCl/OCl−), as an important reactive oxygen species, is speculated to be an indicator of AS caused by Hcy-inducated. Here, a fluorescence nanoprobe LR NPs based on the assembly of pluronic F-127 and probe TR was developed for ClO− detection and imaging during Hcy stress. As expected, LR NPs showed good selectivity and sensitivity for ClO− detection. LR NPs can visualize the fluxes of HClO/ClO− during the stimulation of Hcy induce AS in real time, which demonstrated HClO/ClO− could be performed as an indicator of AS. [Display omitted] • A nano-fluorescent probe (LR NPs) with high sensitivity and selectivity to ClO− was designed and synthesized. • LR NPs was applied to detect endogenous and exogenous ClO− in living cells. • The fluorescent imaging of ClO− caused by Hcy-induced was reported for the first time. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CYSTEINE
*REACTIVE oxygen species
*HOMOCYSTEINE
*HYPOCHLORITES
Subjects
Details
- Language :
- English
- ISSN :
- 01437208
- Volume :
- 213
- Database :
- Academic Search Index
- Journal :
- Dyes & Pigments
- Publication Type :
- Academic Journal
- Accession number :
- 162361924
- Full Text :
- https://doi.org/10.1016/j.dyepig.2023.111163