Cofactors of wheat‐dependent exercise‐induced anaphylaxis increase gastrointestinal gliadin absorption by an inhibition of prostaglandin production.

Keywords: exercise; gliadin; non-steroidal anti-inflammatory drugs; prostaglandin; wheat-dependent exercise-induced anaphylaxis EN exercise gliadin non-steroidal anti-inflammatory drugs prostaglandin wheat-dependent exercise-induced anaphylaxis 359 361 3 03/15/23 20230301 NES 230301 Key messages Bread ingestion combined with exercise or aspirin increased the serum level of wheat gliadins. We measured the blood gliadin levels in patients with WDEIA during a challenge test, using a highly sensitive enzyme-linked immunosorbent assay (ELISA) that can specifically detect wheat gliadin.[[2]] As a result, the blood gliadin level increased preceding the allergic symptoms when induced by the combination of wheat ingestion and exercise, while serum gliadin was not detected or remained at a very low level in the case of the wheat ingestion alone. Blood gliadin levels were elevated for 15-120 min after gluten ingestion; however, no enhancing effects were found for aspirin, alcohol, or exercise on blood gliadin levels. [Extracted from the article]