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Nano-baicalein facilitates chemotherapy in breast cancer by targeting tumor microenvironment.
- Source :
-
International Journal of Pharmaceutics . Mar2023, Vol. 635, pN.PAG-N.PAG. 1p. - Publication Year :
- 2023
-
Abstract
- [Display omitted] • Baicalein-loaded mPEG-PLGA nanoparticles with a high drug-loading rate and stability were developed, which has high biocompatibility and low toxicity. • Baicalein enables to inhibition of the TGF-β/Smad and TGF-β/MAPK signaling pathways and reduces the activation of cancer associated fibroblasts. • PMs-Ba could remodel the tumor microenvironment by baicalein-loaded mPEG-PLGA, contributing to enhancing the anti-tumor impact of adriamycin-loaded mPEG-PLGA. Cancer-associated fibroblasts constitute a significant component in the tumor microenvironment, playing a pivotal role in tumor proliferation, invasion, migration, and metastasis. Consequently, therapy combining chemotherapeutic agents with tumor microenvironment (TME) modulators appears to be a promising avenue for cancer treatment. In this paper, a tumor microenvironment-based mPEG-PLGA nanoparticle loaded with baicalein (PMs-Ba) was constructed for the purpose of improving the tumor microenvironment in cases of triple-negative breast cancer. The results demonstrate that, on the one hand, PMs-Ba was able to inhibit the transforming growth factor β(TGF-β) signaling pathway to avoid the activation of cancer-associated fibroblasts (CAFs), thereby influencing the interstitial microenvironment of the tumor. On the other hand, the agent led to an increase in the infiltration of cytotoxic T cells, activating the tumor immune microenvironment. Meanwhile, in the murine breast cancer model, an intravenous injection of PMs-Ba combined with doxorubicin nanoparticles (PMs-ADM) significantly improved the antitumor effectiveness. These results suggest that baicalein encapsulated in nanoparticles may be a promising strategy for modulating the TME and for adjuvant chemotherapy, signifying a potential TME-remodeling nanoformulation that could enhance the antitumor efficacy of nanotherapeutics. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03785173
- Volume :
- 635
- Database :
- Academic Search Index
- Journal :
- International Journal of Pharmaceutics
- Publication Type :
- Academic Journal
- Accession number :
- 162438923
- Full Text :
- https://doi.org/10.1016/j.ijpharm.2023.122778