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Defluorophosphorylation of fluoroalkyl peroxides for the synthesis of highly substituted furans.
- Source :
-
Green Chemistry . 3/7/2023, Vol. 25 Issue 5, p2000-2010. 11p. - Publication Year :
- 2023
-
Abstract
- Transformation of multifunctional materials with control over site-selectivity and chemical diversity remains challenging. Herein, we present a metal-free, one-pot strategy for the defluorophosphorylation of polyfluoroalkyl peroxides that enables expedient construction of structurally diverse phosphoryl-containing heterocyclic libraries. By judicious choice of reaction conditions, C3,4-diphosphoryl furans and C4-monophosphoryl furans can be easily accessed. In addition, synthetic derivatization of the obtained organophosphorus heteroarenes to value-added monodentate and bidentate phosphines has been demonstrated. Mechanistic studies revealed that regioselective defluorophosphorylation allows divergent product formation in two reaction modes. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14639262
- Volume :
- 25
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Green Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 162485904
- Full Text :
- https://doi.org/10.1039/d2gc04512e