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FGF-21 and GDF-15 are increased in migraine and associated with the severity of migraine-related disability.
- Source :
-
Journal of Headache & Pain . 3/20/2023, Vol. 24 Issue 1, p1-9. 9p. - Publication Year :
- 2023
-
Abstract
- Background: Migraine is a prevalent disorder with significant socioeconomic impact. The impairment of metabolic homeostasis in migraine warrants further investigation. Changes in serum levels of Fibroblast-growth-factor 21 (FGF-21) and Growth-differentiation-factor 15 (GDF-15) are characteristic of some metabolic and mitochondrial diseases. This study aimed to assess whether the presence of migraine affects serum levels of FGF-21 and GDF-15, and taking metabolic disorders into account as potential confounding factors. Methods: We collected serum samples from 221 migraine patients (153 episodic migraineurs and 68 chronic migraineurs) and 124 healthy controls. The serum concentrations of FGF-21 and GDF-15 were measured using an enzyme-linked immunosorbent assay (ELISA) based approach. Clinical variables, including monthly headache days, peak headache pain intensity, the 6-item Headache Impact Test (HIT-6), and the Migraine Disability Assessment (MIDAS), were also addressed. The associations between the clinical variables of migraine patients and serum levels of FGF-21 and GDF-15 were studied. Results: In the multiple regression that corrected for age, we found that the serum levels of FGF-21 and GDF-15 were significantly higher in migraine sufferers than in healthy controls. A significant elevation in serum concentration of FGF-21, but not GDF-15, was observed in patients with chronic migraine (CM) compared to those with episodic migraine (EM). Regarding migraine-related disability, higher scores on the HIT-6 and MIDAS were associated with higher levels of FGF-21 and GDF-15. For the receiver operating characteristic (ROC) analysis, the diagnosis of migraine using GDF-15 showed that the area under the ROC curve (AUC) was 0.801 and the AUC of chronic migraine was 0.880. Conclusion: Serum GDF-15 and FGF-21 levels are increased in patients with migraine and associated with the severity of migraine-related disability. [ABSTRACT FROM AUTHOR]
- Subjects :
- *FIBROBLAST growth factors
*BIOMARKERS
*CHRONIC pain
*MULTIPLE regression analysis
*METABOLIC disorders
*RISK assessment
*DISABILITIES
*ENZYME-linked immunosorbent assay
*RESEARCH funding
*RECEIVER operating characteristic curves
*GROWTH differentiation factors
*BLOOD
*DISEASE complications
MIGRAINE risk factors
MIGRAINE complications
Subjects
Details
- Language :
- English
- ISSN :
- 11292369
- Volume :
- 24
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Headache & Pain
- Publication Type :
- Academic Journal
- Accession number :
- 162550356
- Full Text :
- https://doi.org/10.1186/s10194-023-01563-8