Évaluation de l’effet des extraits des feuilles de Thymus vulgaris L. sur le profil lipidique des souris sous un régime riche en cholestérol.

Hyperlipidemia is one of the major risk factors contributing to the severity of cardiovascular disease. Treatment of hyperlipidemia involves diet control and the use of lipid-lowering drugs. However, some patients cannot tolerate the side effects of these drugs, so modern medicine is turning to traditional medicine in search of new therapeutic agents. The objective of this study is the determination of the effect of aqueous and hydroalcoholic extracts of Thymus vulgaris L. administered orally at a dose of 200 mg/kg body weight on the lipid profile — total cholesterol (TC), triglycerides (TG), low-density lipoproteins (LDL), very lowdensity lipoproteins (VLDL), and high-density lipoproteins (HDL) — of mice on a high cholesterol diet. Determination of lipid parameters after 30 days of treatment showed a significant decrease in the level of TC, TG, LDL, and VLDL with a non-significant increase in HDL level. These results demonstrated that Thymus vulgaris extracts have hypolipidic activity and could be used for the prevention of disorders associated with hyperlipidemia. [ABSTRACT FROM AUTHOR]