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Does memory improve with age? CD85j (ILT-2/LIR-1) expression on CD8+ T cells correlates with‘memory inflation’ in human cytomegalovirus infection.
- Source :
-
Immunology & Cell Biology . Apr2005, Vol. 83 Issue 2, p182-188. 7p. - Publication Year :
- 2005
-
Abstract
- CMV-specific memory CD8+ T cells accumulate over time to reach high frequencies amongst peripheral blood lymphocytes– a phenomenon termed‘memory inflation’. Using tetramer staining on samples from a large number of subjects and multivariate regression analysis, we were able to relate this to the phenotype of CD8+ T cells. We made the following observations: (i) CD85j (ILT-2/LIR-1) was highly expressed alongside CD57– an established effector memory marker– on CMV-specific CD8+ T cells; (ii) on CD8+ T cells as a whole, with increasing age, CD57 and CD85j (ILT-2/LIR-1) expression increased whereas CCR7 expression decreased, indicating increasing maturation of the total CD8+ T-cell compartment with age; (iii) unit increases in the percentage of CMV-specific CD8+ T cells expressing CD57 and CD85j (ILT-2/LIR-1) were associated with incremental expansion of these T-cell populations; (iv) CMV seropositivity is associated with a marked effect on the overall phenotype of CD8+ T cells (at any given age, CMV seropositivity is associated with an 18.7% increase in CD85j (ILT-2/LIR-1) expression); and (v) from our observations we estimated from this an apparent‘ageing effect’ of CMV on CD8+ T cells of 35.4 years. The data presented are consistent with a predictable, unidirectional and linear model of virus specific T-cell differentiation and maturation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08189641
- Volume :
- 83
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Immunology & Cell Biology
- Publication Type :
- Academic Journal
- Accession number :
- 16258431
- Full Text :
- https://doi.org/10.1111/j.1440-1711.2005.01321.x