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Identification and reduction of hazardous drug surface contamination through the use of a novel closed-system transfer device coupled with a point-of-care hazardous drug detection system.
- Source :
-
American Journal of Health-System Pharmacy . Apr2023, Vol. 80 Issue 7, p435-444. 10p. 1 Diagram, 2 Charts. - Publication Year :
- 2023
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Abstract
- Purpose Minimizing hazardous drug (HD) contamination is critical for protecting the health of healthcare workers (HCWs) and patients. Alarmingly, widespread HD contamination has been documented across a variety of clinical settings. Quantitative wipe sampling presents significant time and cost barriers, resulting in routine monitoring adherence rates around 25%. Closed-system drug transfer devices (CSTDs) and qualitative point-of-care tests can be implemented to overcome these barriers. Methods In this study, we tested the effects of the BD PhaSeal Optima (Becton, Dickinson and Company), a recently introduced CSTD, on HD contamination at 2 chemotherapy infusion centers. Wipe samples were taken at 29 workstations at each location prior to and a year following CSTD implementation. Additionally, traditional liquid chromatography with mass spectrometry (LCMS/MS) analyses were compared against a novel lateral flow immunoassay HD testing device (BD HD Check; Becton, Dickinson and Company) to determine the validity of the qualitative assay. Results We found a 46% reduction in HD contamination after incorporating the CSTD into clinical workflows. Across time points and sites, HD contamination reported by the BD HD Check device was 91% accurate against LCMS/MS and 98% accurate within its limits of detection. Conclusion Collectively, the evaluated CSTD and lateral flow immunoassay device may help to reduce HD contamination and provide real-time measures of contamination, respectively. As part of a multifaceted approach, these devices may help minimize barriers to routine monitoring, ultimately improving the safety of HCWs and patients. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10792082
- Volume :
- 80
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- American Journal of Health-System Pharmacy
- Publication Type :
- Academic Journal
- Accession number :
- 162631650
- Full Text :
- https://doi.org/10.1093/ajhp/zxac336