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Immune thrombocytopenia and risk of stroke: Evidence from a nationwide population-based cohort study.
- Source :
-
International Journal of Stroke . Apr2023, Vol. 18 Issue 4, p408-415. 8p. - Publication Year :
- 2023
-
Abstract
- Background: Research investigating differences in the overall stroke risk between individuals with and without immune thrombocytopenia (ITP) is lacking. Methods: This real-world study used the National Health Insurance Research Database (NHIRD). Risk of stroke was compared between 13,085 individuals with ITP enrolled between 1 January 2000 and 31 December 2015 and a control cohort of 52,340 individuals without ITP (1:4 ratio propensity score–matched by age, sex, index year, relevant comorbidities, and medications). Sub-distribution hazards models were used to estimate adjusted sub-distribution hazard ratio (SHR) and 95% confidence intervals (CIs), with the non-ITP group as the control group. Results: Of the 65,425 participants, 13,085 had ITP, 63.3% were women, and the mean age was 52.59 years. The risk of both ischemic and hemorrhagic stroke was 1.14 times (adjusted SHR 1.14, 95% CI, 1.07–1.22) and 1.93 times (adjusted SHR 1.93, 95% CI, 1.70–2.20) higher in the ITP group than in controls. Patients with ITP in the 20- to 29-year subgroup had a higher risk of new-onset stroke (adjusted SHR, 4.06 (95% CI, 2.72–6.07), p value for interaction <0.01) than those aged 20–29 years without ITP. Individuals with severe ITP with splenectomy had a 1.79 times higher overall stroke risk than those without. Conclusions: ITP is associated with increased risk of both ischemic and hemorrhagic stroke. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17474930
- Volume :
- 18
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- International Journal of Stroke
- Publication Type :
- Academic Journal
- Accession number :
- 162669861
- Full Text :
- https://doi.org/10.1177/17474930221125556