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Prognostic factors for recurrence in patients with surgically resected non-small cell lung cancer.
- Source :
-
Contemporary Oncology / Współczesna Onkologia . 2022, Vol. 26 Issue 3, p239-246. 8p. - Publication Year :
- 2022
-
Abstract
- Introduction: Patients with lung cancer receive treatment according to National Cancer Comprehensive Network (NCCN) standards. However, disease recurrence is reported in about 30% of patients during the first five years. Our study aimed to establish independent predictors of lung cancer recurrence. Material and methods: 104 patients with definitive treatment for nonsmall-cell lung carcinoma receiving standard adjuvant chemotherapy in the period 2014-2018 in our cancer center were retrospectively reviewed. The prognostic significance of five routine immunohistochemical (IHC) markers was examined. Results: During the follow-up period disease recurrence occurred in 42 (40.4%) of the 104 enrolled patients. The median recurrence-free survival was 56.3 months, range 4-84.0 months (95% CI = 46.866-65.683). The recurrence-free survival rate was 58.8%. The frequencies of locoregional recurrence, lung recurrence, kidney, bone, lymph nodes of the neck, liver, and brain recurrence were 23.8%, 21.5%, 16.7%, 9.5%, 9.5%, 9.5% and 9.5%, respectively. Conclusions: Using the Cox regression model, category T, histological differentiation, and smoking status were identified as independent predictors of disease recurrence. The studied biological markers (PD-L1, Ki67, p53, epidermal growth factor receptor, and ALK) did not help the model predict disease recurrence. For statistical reliability, it is necessary to conduct a study on a larger cohort of patients and compare the mutual influence of several biomarkers. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14282526
- Volume :
- 26
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Contemporary Oncology / Współczesna Onkologia
- Publication Type :
- Academic Journal
- Accession number :
- 162740752
- Full Text :
- https://doi.org/10.5114/wo.2022.120638