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p53 regulates the mitochondrial immune checkpoint.
- Source :
-
Trends in Immunology . Apr2023, Vol. 44 Issue 4, p245-247. 3p. - Publication Year :
- 2023
-
Abstract
- Mitochondrial outer membrane permeabilization (MOMP) is crucial for the cytosolic accumulation of mitochondrial DNA (mtDNA) species that are required to jumpstart innate and adaptive immunity. Recent data reported by Ghosh et al. suggest that tumor protein p53 regulates MOMP-dependent type I interferon (IFN) production, not only via MOMP-promoting effects, but also by directing mtDNA-degrading exonucleases to proteasomal processing. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14714906
- Volume :
- 44
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Trends in Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 162758806
- Full Text :
- https://doi.org/10.1016/j.it.2023.03.001