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Glucose oxidase-loaded colloidal stable WS2 nanobowls for combined starvation/photothermal therapy of colorectal tumors.

Authors :
Chen, Zheng
Zheng, Xiaoyi
Zhao, Jiulong
Tang, Jingwen
Hu, Lianghao
Wang, Shige
Source :
International Journal of Pharmaceutics. Apr2023, Vol. 636, pN.PAG-N.PAG. 1p.
Publication Year :
2023

Abstract

[Display omitted] Glucose is used as an important nutrient to support cell growth. The glucose oxidase (GOx) can transform glucose into gluconic acid and toxic H 2 O 2 , which can be used for tumor starvation therapy. However, the leakage of GOx may cause severe side effects to the normal tissue. To prevent the accidental leakage of GOx, this study proposes the chemical modification of GOx on the photothermal transducing agent surface, to realize the safe and combined starvation and photothermal therapy of colorectal tumors. Polyvinylpyrrolidone (PVP)-modified WS 2 nanobowls (WS 2 -PVP) as a photothermal transducing agent were produced using a one-pot preparation method. Then, α-lipoic acid (LA) molecules were immobilized at the sulfur-deficient sites on the surface of WS 2 nanobowls to afford the chemical loading of GOx through amide bonds. Under the irradiation of a near-infrared laser (808 nm), thermal energy is generated by WS 2 to kill colorectal cancer cells locally. The photothermal conversion efficiency of WS 2 -PVP-LA was 27.2%. This study is anticipated to open up an alternative avenue for the rational design of multifunctional nanotherapeutics for tumor therapy. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03785173
Volume :
636
Database :
Academic Search Index
Journal :
International Journal of Pharmaceutics
Publication Type :
Academic Journal
Accession number :
162761243
Full Text :
https://doi.org/10.1016/j.ijpharm.2023.122848