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Myeloperoxidase and interleukin-8 levels in chronic sinusitis.
- Source :
-
Clinical & Experimental Allergy . Jun1997, Vol. 27 Issue 6, p672-675. 4p. - Publication Year :
- 1997
-
Abstract
- We have recently phenotyped inflammation in non-infectious allergic and non-allergic chronic maxillary sinusitis using sinus biopsies and lavage fluids. In this first paper, we have concentrated our work on the eosinophil, T cell, mast cell and macrophage infiltrates. However, many unresolved questions remain and particularly the role of neutrophils needed to be addressed. In the present study, we focused on the neutrophilic inflammation: myeloperoxidase (MPO) and interleukin-8 (IL-8) were measured by immunoassays and neutrophils were enumerated by conventional staining in the sinus lavage fluids of 16 patient with chronic sinusitis and six control subjects. Both MPO and IL-8 levels were significantly higher in patients than in controls (P<0.01) and 0.005, respectively). There was a significant correlation between MPO levels and neutrophil numbers, and between MPO and IL-8 levels in the sinus lavage fluid (P<0.0001, Spearman rank correlation). The presence of high levels of IL-8 in the lavage fluids of patients suffering from chronic sinusitis, levels which correlate with those of MPO, suggests that this cytokine may activate neutrophils in this chronic disease. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09547894
- Volume :
- 27
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Clinical & Experimental Allergy
- Publication Type :
- Academic Journal
- Accession number :
- 16278816
- Full Text :
- https://doi.org/10.1111/j.1365-2222.1997.tb01195.x