Tigliane-Type Diterpenoids from the Seeds of Croton tiglium.

A new tigliane-type diterpenoid (1) and three known analogues (2−4) were isolated from the seeds of Croton tiglium. Extensive spectroscopic analyses, especially the 2D NMR experiments were used to determine their structures. The absolute configuration of 1 was defined by single-crystal X-ray diffraction data. The cytotoxicity 1−4 was evaluated against melanoma cell line A375, and the results showed that compounds 1, 3, and 4 exhibited certain cytotoxicities [ABSTRACT FROM AUTHOR]