(8S, 9R)-Dihydroisoflavipucine, a New Isoflavipucine Derivative from the Endophytic Fungi Botryosphaeria dothidea.

A new isoflavipucine derivative, (8S, 9R)-dihydroisoflavipucine (1), is isolated from an ethyl acetate extract of endophytic fungi Botryosphaeria dothidea (D4-2) derived from Taxus mairei. The structure of 1 is elucidated based on nuclear magnetic resonance, circular dichroism, and mass spectrometry. The antiproliferative activity of the isolates against breast cancer cells MDA-MB-231, MCF7 and 4T1 are evaluated. [ABSTRACT FROM AUTHOR]