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Electrochemical synthesis of 5-trifluoroethyl dihydrobenzimidazo[2,1-a] isoquinolines from pendent unactivated alkenes via radical relay.
- Source :
-
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry . Apr2023, Vol. 119, pN.PAG-N.PAG. 1p. - Publication Year :
- 2023
-
Abstract
- [Display omitted] An electrochemical radical relay method for direct access to 5-(2,2,2-trifluoro)ethyl dihydrobenzimidazo[2,1- a ]isoquinoline derivatives from benzimidazole-tethered pendent unactivated alkenes in an undivided cell is developed. This method is applicable to Langlois reagent and difluoro analog, tolerates a wide range of functional groups and activated sp3 C H bonds, and obviates the need for external oxidants. The so-formed heterocycles display good fungicidal activities, especially against Botrytis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00404039
- Volume :
- 119
- Database :
- Academic Search Index
- Journal :
- Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 162890666
- Full Text :
- https://doi.org/10.1016/j.tetlet.2023.154410