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Perspectives on current and emerging therapies for immunoglobulin G4-related disease.
- Source :
-
Modern Rheumatology . Mar2023, Vol. 33 Issue 2, p229-236. 8p. - Publication Year :
- 2023
-
Abstract
- Understanding of the pathophysiology of immunoglobulin G4-related disease (IgG4-RD) over the last dozen years has opened the door to a variety of targeted treatment approaches. Glucocorticoids are an effective treatment for IgG4-RD if used at a sufficiently high dose, but disease flares are common during or after glucocorticoid tapers and these medications seldom lead to long-term, treatment-free remissions. Moreover, their long-term use in a disease that frequently affects middle-aged to elderly individuals and often causes major pancreatic damage leads to a narrow therapeutic index. Biological therapies offer the possibility of effective disease control with fewer treatment-associated side effects. Promising avenues of investigation include B-cell depletion, immunomodulation of B-cell subsets, interference with co-stimulation, Bruton's tyrosine kinase inhibition, and Signaling lymphocytic activation molecule F7-directed treatment. [ABSTRACT FROM AUTHOR]
- Subjects :
- *KINASES
*BRUTON tyrosine kinase
*SEROTHERAPY
*OLDER people
*PANCREATIC cysts
Subjects
Details
- Language :
- English
- ISSN :
- 14397595
- Volume :
- 33
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Modern Rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 162898515
- Full Text :
- https://doi.org/10.1093/mr/roac141