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Findings on Diagnostic Magnetic Resonance Imaging Before Radiotherapy for Prostate Cancer.
- Source :
-
Canadian Association of Radiologists Journal . May2023, Vol. 74 Issue 2, p382-387. 6p. - Publication Year :
- 2023
-
Abstract
- Purpose: Pre-treatment diagnostic magnetic resonance imaging (MRI) is used in prostate cancer detection and staging; however, little is known about its potential for radiotherapy treatment decision, or its prognostic value. We investigated the findings on pre-treatment MRI and its potential influence on treatment decisions, and its ability to predict biochemical recurrence in patients treated with radiotherapy. Methods: Files of patients treated by radiotherapy from 2014 to 2022 were searched for if they had had an MRI within 12 months before radiotherapy. Prostate Imaging Reporting & Data System (PI-RADS) score, index lesion diameter and the presence of organ confined disease or extra-prostatic extension were correlated with their Cancer of the Prostate Risk Assessment (CAPRA) score. Distribution of radiological and clinical features between groups were estimated using a chi-squared test. Results: Out of 1280 patients, 314 (24.5%) had an MRI. The distribution depended on the treatment received: 22.5% who received low-dose rate (LDR) brachytherapy as monotherapy, 24.0% treated with high-dose rate (HDR) boost and 32.0% treated with external-beam radiotherapy (EBRT) (P =.017). The CAPRA score significantly correlated with the PI-RADS score (r =.342, P <.01) and the diameter of the index lesion (r =.473, P <.01). A clinically significant number of 22% patients with CAPRA ≤ 3 disease presented with lesions ≥15 mm and were less likely to be treated with LDR monotherapy (P <.01). 39 patients had a recurrence, only 5 had an MRI: 4 had a lesion of ≥20 mm and 3 a seminal vesicle invasion. Conclusion: More than twenty percent of patients with CAPRA ≤3 presented on MRI a ≥15 mm lesion. An MRI could potentially affect treatment choice, and although exploratory our results suggest an important prognostic potential. Visual Abstract [ABSTRACT FROM AUTHOR]
- Subjects :
- *RESEARCH
*CANCER invasiveness
*MAGNETIC resonance imaging
*CANCER relapse
*ACQUISITION of data
*DOSE-response relationship (Radiation)
*TUMOR classification
*MEDICAL records
*DESCRIPTIVE statistics
*CHI-squared test
*RESEARCH funding
*SENSITIVITY & specificity (Statistics)
*DECISION making in clinical medicine
*RADIOISOTOPE brachytherapy
*PROSTATE tumors
Subjects
Details
- Language :
- English
- ISSN :
- 08465371
- Volume :
- 74
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Canadian Association of Radiologists Journal
- Publication Type :
- Academic Journal
- Accession number :
- 162938644
- Full Text :
- https://doi.org/10.1177/08465371221137278