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Preparation and comparison of dialdehyde derivatives of polysaccharides as cross-linking agents.
- Source :
-
International Journal of Biological Macromolecules . May2023, Vol. 236, pN.PAG-N.PAG. 1p. - Publication Year :
- 2023
-
Abstract
- Dialdehyde-based cross-linking agents are widely used in the cross-linking of amino group-containing macromolecules. However, the most commonly used cross-linking agents, glutaraldehyde (GA) and genipin (GP), have safety issues. In this study, a series of dialdehyde derivatives of polysaccharides (DADPs) were prepared by oxidation of polysaccharides, and their biocompatibility and cross-linking properties were tested using chitosan as a model macromolecule. The DADPs showed outstanding cross-linking and gelation properties comparable to GA and GP. The DADPs and hydrogels cross-linked with the DADPs exhibited excellent cytocompatibility and hemocompatibility with different concentrations while significant cytotoxicity was observed in GA and GP. The experimental results showed that the cross-linking effect of DADPs increased along with their oxidation degree. The outstanding cross-linking effect of the DADPs show a potential for use in the cross-linking of biomacromolecules with amino groups and could be an adequate alternative to existing cross-linkers. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01418130
- Volume :
- 236
- Database :
- Academic Search Index
- Journal :
- International Journal of Biological Macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 162977170
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2023.123913