Bis-chalcones: A review of synthetic methodologies and anti-inflammatory effects.

Chalcones are bioactive molecules of natural and synthetic sources, whose physicochemical properties, reactivity, and biological activities are well-known among the scientific community. However, there are many molecules strictly related to chalcones with significantly less recognition like bis -chalcones. Several studies indicated that bis -chalcones have advantages over chalcones in specific bioactivities like anti-inflammatory activity. This review article describes the chemical structure and chemical properties of bis -chalcones, as well as the methods reported in the literature for the synthesis of these compounds highlighting the most recent developments. Finally, the anti-inflammatory activity of bis -chalcones is described, emphasizing the active structures found in literature and their mechanisms of action. [Display omitted] • Bis -chalcones are a subclass of chalcones that earned considerable interest. • Chemical synthesis of bis -chalcones based on established knowledge on chalcones. • Improvement of classic synthetic methodologies with new reaction conditions. • Very few bis- chalcones are associated with anti-inflammatory activity. • More studies on anti-inflammatory bis -chalcones are required to establish a SAR. [ABSTRACT FROM AUTHOR]