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Prognostic factors and Doxorubicin involved in malignant progression of meningioma.
- Source :
-
Scientific Reports . 4/6/2023, Vol. 13 Issue 1, p1-12. 12p. - Publication Year :
- 2023
-
Abstract
- Meningioma was the most primary intracranial tumor, but the molecular characteristics and the treatment of malignant meningioma were still unclear. Nine malignant progression-related genes based prognostic signatures were identified by transcriptome analysis between benign meningioma and malignant meningioma. The external dataset GEO136661 and quantitative Real-time Polymerase Chain Reaction were used to verify the prognostic factors. has-miR-3605-5p, hsa-miR-664b-5p, PNRC2, BTBD8, EXTL2, SLFN13, DGKD, NSD2, and BVES were closed with malignant progression. Moreover, Doxorubicin was identified by Connectivity Map website with the differential malignant progression-related genes. CCK-8 assay, Edu assay, wound healing assay, and trans-well experiment were used to reveal that Doxorubicin could inhibit proliferation, migration and invasion of IOMM-Lee Cells. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PROGNOSIS
*MENINGIOMA
*INTRACRANIAL tumors
*POLYMERASE chain reaction
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 13
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Scientific Reports
- Publication Type :
- Academic Journal
- Accession number :
- 163004926
- Full Text :
- https://doi.org/10.1038/s41598-023-28996-0