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Concomitant Diseases and Co-contribution on Progression of Liver Stiffness in Patients with Hepatitis B Virus Infection.
- Source :
-
Digestive Diseases & Sciences . Apr2023, Vol. 68 Issue 4, p1605-1614. 10p. - Publication Year :
- 2023
-
Abstract
- Background: The association between hepatitis B and concomitant diseases, such as fatty liver, T2DM, MetS, and Hp infection, remains unclear. Aim: The present study was to illustrate the association and explore the co-contribution on abnormal transaminase and progression of liver stiffness. Methods: A total of 95,998 participants underwent HBsAg screening in West China Hospital from 2014 to 2017. Multivariable logistic regression was used to determine the adjusted odds ratios. Results: The prevalence of HBsAg-positive rate was 8.30% of our included study population. HBsAg positive was associated with negative risk of fatty liver (odds ratio [OR] 0.71, 95% confidence interval [CI] 0.65–0.78, p < 0.001) and MetS (OR 0.74, 95% CI 0.67–0.84, p < 0.001), and with positive risk of Hp infection (OR 1.09, 95% CI 1.02–1.17, p = 0.012) and T2DM (OR 1.18, 95% CI 1.01–1.40, p = 0.043). Besides, HBsAg-positive patients with T2DM had higher risk of elevated ALT (OR 2.09, 95% CI 1.69–2.83, p < 0.001 vs OR 1.59, 95% CI 1.51–1.68, p < 0.001), AST (OR 2.69, 95% CI 1.98–3.65, p < 0.001 vs OR 1.89, 95% CI 1.76–2.02, p < 0.001) than HBV alone. In addition to HBV, T2DM also can increase the risk of liver fibrosis (OR 3.23, 95% CI 1.35–7.71, p = 0.008) and cirrhosis (OR 4.31, 95% CI 1.41–13.20, p = 0.010). Conclusion: Hepatitis B patients have a lower risk of fatty liver and MetS, and a higher risk of T2DM and Hp infection. Besides, T2DM might be possibly associated with abnormal liver transaminase and fibrosis progression in HBsAg-positive patients. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01632116
- Volume :
- 68
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Digestive Diseases & Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 163098849
- Full Text :
- https://doi.org/10.1007/s10620-022-07695-2