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Copper‐Catalyzed Enantioselective Trifluoromethoxylation of Propargyl Sulfonates.
- Source :
-
Angewandte Chemie . 4/24/2023, Vol. 135 Issue 18, p1-6. 6p. - Publication Year :
- 2023
-
Abstract
- Due to the strong electron‐withdrawing nature and high lipophilicity of trifluoromethoxy group (OCF3), methods for introducing OCF3 into organic molecules are in high demand. However, the research area of direct enantioselective trifluoromethoxylation is still in the embryonic stage, with limited enantioselectivity and/or reaction types. Here, we describe the first copper‐catalyzed enantioselective trifluoromethoxylation of propargyl sulfonates using trifluoromethyl arylsulfonate (TFMS) as the trifluoromethoxy source in up to 96 % ee. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SULFONATES
*SUPPLY & demand
*COPPER
*LIPOPHILICITY
Subjects
Details
- Language :
- English
- ISSN :
- 00448249
- Volume :
- 135
- Issue :
- 18
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie
- Publication Type :
- Academic Journal
- Accession number :
- 163112993
- Full Text :
- https://doi.org/10.1002/ange.202218919