Role and therapeutic potential of gelsolin in atherosclerosis.

Atherosclerosis is the major pathophysiological basis of a variety of cardiovascular diseases and has been recognized as a lipid-driven chronic inflammatory disease. Gelsolin (GSN) is a member of the GSN family. The main function of GSN is to cut and seal actin filaments to regulate the cytoskeleton and participate in a variety of biological functions, such as cell movement, morphological changes, metabolism, apoptosis and phagocytosis. Recently, more and more evidences have demonstrated that GSN is Closely related to atherosclerosis, involving lipid metabolism, inflammation, cell proliferation, migration and thrombosis. This article reviews the role of GSN in atherosclerosis from inflammation, apoptosis, angiogenesis and thrombosis. • This paper introduces the comprehensive structure, function, and distribution of GSN in the body. • Evidence gathered for link between GSN and pathological basis of atherosclerosis. • On the basis of research, it is speculated that the target of GSN on atherosclerosis. • Proposes the possibility of GSN as a biomarker for atherosclerosis. [ABSTRACT FROM AUTHOR]