Synthesis, characterization and comprehensive study of a 3D Co(II) coordination polymer antibacterial activity.

• A stable 3D Co(II)-based coordination polymer was synthesized and characterized. • The solvent stability test was conducted in various common organic solvents. • The cytotoxicity was evaluated by MTT assays against HEK-293 cell line. • This polymer showed significant antibacterial activity against the investigated strains. • This polymer recognized as a desirable antibacterial agent. The current work reports the facile synthesis and complete characterization of a stable 3D Co(II)-based coordination polymer, namely Co(HCOO) 2 (4,4′-bpy) (1), (4,4′-bpy=4,4′-bipyridine), prepared via two different synthetic methods including solvothermal reaction and reflux method. The Co-coordination polymer was fully characterized by 1H NMR, FT-IR, FE-SEM, TGA, ICP, BET, single-crystal X-ray crystallography, powder X-ray diffraction crystallography, and VSM analysis. The cell treatment with Co-coordination polymer was evaluated, and the cytotoxicity study was done by MTT assays against the HEK-293 cell line. Furthermore, the antibacterial properties of Co-coordination polymer nanoparticles were investigated. The Co-coordination polymer showed significant antibacterial properties against the selected strains of Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria. A stable 3D Co(II)-based coordination polymer, Co(HCOO) 2 (4,4′-bpy), was synthesized via two facile different synthetic methods, including solvothermal reaction and reflux method. It was fully characterized and the cytotoxicity was evaluated by MTT assays against HEK-293 cell line. The Co-coordination polymer showed significant antibacterial activity against the strains of Gram-negative and Gram-positive bacteria. The antibacterial properties of this polymer are due to a combination of physicochemical properties such as solubility, shape, size and specific surface area. [Display omitted] [ABSTRACT FROM AUTHOR]