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In vivo serotonin transporter and 1A receptor binding potential and ecological momentary assessment (EMA) of stress in major depression and suicidal behavior.

Authors :
Bartlett, Elizabeth A.
Zanderigo, Francesca
Stanley, Barbara
Choo, Tse-Hwei
Galfalvy, Hanga C.
Pantazatos, Spiro P.
Sublette, M. Elizabeth
Miller, Jeffrey M.
Oquendo, Maria A.
Mann, J. John
Source :
European Neuropsychopharmacology. May2023, Vol. 70, p1-13. 13p.
Publication Year :
2023

Abstract

We examined relationships between the serotonin system and stress in major depression and suicidal behavior. Twenty-five medication-free depressed participants (13 suicide attempters) underwent same-day [11C]DASB and [11C]CUMI-101 positron emission tomography (PET) imaging. Binding potential (BP ND) to the serotonin transporter (5-HTT) and serotonin 1A (5-HT 1A) receptor, respectively, was quantified using the NRU 5-HT atlas, reflecting distinct spatial distributions of multiple serotonin targets. Ecological momentary assessment (EMA) measured current stress over one week proximal to imaging. EMA stress did not differ between attempters and non-attempters. In all depressed participants, 5-HTT and 5-HT 1A BP ND were unrelated to EMA stress. There were region-specific effects of 5-HTT (p=0.002) and 5-HT 1A BP ND (p=0.03) in attempters vs. nonattempters. In attempters, region-specific associations between 5-HTT (p=0.03) and 5-HT 1A (p=0.005) BP ND and EMA stress emerged. While no post-hoc 5-HTT BP ND correlations were significant, 5-HT 1A BP ND correlated positively with EMA stress in attempters in 9/10 regions (p-values<0.007), including the entire cortex except the largely occipital region 5. Brodmann-based regional analyses found diminished effects for 5-HTT and subcortically localized positive corrrelations between 5-HT 1A and EMA stress, in attempters only. Given comparable depression severity and childhood and current stress between attempters and nonattempters, lower 5-HTT binding in attempters vs. nonattempters may suggest a biological risk marker. Localized lower 5-HTT and widespread higher 5-HT 1A binding with stress among attempters specifically may suggest that a serotonergic phenotype might be a key determinant of risk or resiliency for suicidal behavior. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0924977X
Volume :
70
Database :
Academic Search Index
Journal :
European Neuropsychopharmacology
Publication Type :
Academic Journal
Accession number :
163185273
Full Text :
https://doi.org/10.1016/j.euroneuro.2023.01.006