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Iodine substitution compromises the aggregation-induced emission (AIE) property and enhances the biothiol sensitivity of quinoline–malononitrile-based fluorescent probes.
- Source :
-
Dyes & Pigments . Jul2023, Vol. 215, pN.PAG-N.PAG. 1p. - Publication Year :
- 2023
-
Abstract
- The development of long-wavelength fluorescent probes with a pH working range from weakly acidic to neutral is important for cell-imaging studies. In this study, quinoline-malononitrile (QM)-based fluorescent probes without and with iodine substitution surrounding its phenolic ring are synthesized. The iodine substitution manner was found to compromise the aggregation-induced emission of QM whilst resulting in a significantly enhanced sensitivity for biothiols including l -cystine (L-Cys) detection in weakly acidic to neutral aqueous buffer solutions through reducing the pKa of the QM fluorogen. The probe also effectively achieved the fluorescence visualization of the fluctuation in L-Cys levels in cells. [Display omitted] • Iodine substitution compromises the AIE property of QM dye. • pKa of QM dye is reduced by iodine substitution. • Iodine-substituted QM dye works at weakly acidic and neutral pH. • Visualization of fluctuations in biothiol level in cells is achieved. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01437208
- Volume :
- 215
- Database :
- Academic Search Index
- Journal :
- Dyes & Pigments
- Publication Type :
- Academic Journal
- Accession number :
- 163185950
- Full Text :
- https://doi.org/10.1016/j.dyepig.2023.111246