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Tracking tumor-specific CD8+ T cell responses.
- Source :
-
Trends in Immunology . May2023, Vol. 44 Issue 5, p326-328. 3p. - Publication Year :
- 2023
-
Abstract
- In a recent article, Puig-Saus et al. computationally predict and experimentally validate neoantigen-specific T cell responses in patients with melanoma. They identify a restricted set of neoantigens recognized by polyclonal CD8+ T cells as a unique feature of anti-PD-1 responders and engineer autologous tumor-responsive T cells expressing neoantigen-specific TCRs, providing proof-of-concept for future cellular therapies. [ABSTRACT FROM AUTHOR]
- Subjects :
- *T cells
*CD8 antigen
*CELLULAR therapy
*ENGINEERS
Subjects
Details
- Language :
- English
- ISSN :
- 14714906
- Volume :
- 44
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Trends in Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 163186246
- Full Text :
- https://doi.org/10.1016/j.it.2023.03.012