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Nano‐gold micelles loaded Dox and Elacridar for reversing drug resistance of breast cancer.
- Source :
-
IET Nanobiotechnology (Wiley-Blackwell) . Apr2023, Vol. 17 Issue 2, p49-60. 12p. - Publication Year :
- 2023
-
Abstract
- The aim of this study was to provide a new effective carrier for rescuing the sensitivity of drug‐resistant in breast cancer cells. Nano‐gold micelles loaded with Dox and Elacridar (FP‐ssD@A‐E) were chemically synthesised. With the increase in the amount of Dox and Elacridar, the encapsulation rate of FP‐ssD@A‐E gradually increased, and the drug loading rate gradually decreased. FP‐ss@A‐E had a sustained‐release effect. Dox, Elacridar, FP‐ss@AuNPs, and FP‐ssD@A‐E significantly improved cell apoptosis, in which, FP‐ssD@A‐E was the most significant. FP‐ssD@A‐E significantly decreased the cell viability and improved the Dox uptake. The levels of VEGFR‐1, P‐gp, IL‐6, and i‐NOS were significantly decreased after Dox, Dox + Elacridar, FP‐ss@AuNPs, and FP‐ssD@A‐E treatment. It was worth noting that FP‐ssD@A‐E had the most significant effects. The prepared FP‐ssD@A‐E micelles, which were spherical in shape, uniform in particle size distribution, and had good drug loading performance and encapsulation efficiency. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17518741
- Volume :
- 17
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- IET Nanobiotechnology (Wiley-Blackwell)
- Publication Type :
- Academic Journal
- Accession number :
- 163191213
- Full Text :
- https://doi.org/10.1049/nbt2.12102