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Predictors of relapse in Takayasu arteritis.
- Source :
-
European Journal of Internal Medicine . May2023, Vol. 111, p105-112. 8p. - Publication Year :
- 2023
-
Abstract
- • Disease relapse is common in patients with Takayasu arteritis. • Disease duration <24 months, history of relapse, history of cerebrovascular events, aneurysms, ascending aorta or aortic arch involvement, number of involved arteries ≥6, elevated white blood cell count, and elevated high-sensitivity C-reactive protein level at baseline independently increased the risk of relapse. • With good discrimination and calibration, this prediction model can help to identify high-risk patients for relapse and assist clinical decision-making. Takayasu arteritis (TAK) is a large-vessel vasculitis with high relapse rate. Longitudinal studies identifying risk factors of relapse are limited. We aimed to analyze the associated factors and develop a risk prediction model for relapse. We analyzed the associated factors for relapse in a prospective cohort of 549 TAK patients from the Chinese Registry of Systemic Vasculitis cohort between June 2014 and December 2021 using univariate and multivariate Cox regression analyses. We also developed a prediction model for relapse, and stratified patients into low-, medium-, and high-risk groups. Discrimination and calibration were measured using C-index and calibration plots. At a median follow-up of 44 (IQR 26–62) months, 276 (50.3%) patients experienced relapses. History of relapse (HR 2.78 [2.14–3.60]), disease duration <24 months (HR 1.78 [1.37–2.32]), history of cerebrovascular events (HR 1.55 [1.12–2.16]), aneurysm (HR 1.49 [1.10–2.04], ascending aorta or aortic arch involvement (HR 1.37 [1.05–1.79]), elevated high-sensitivity C-reactive protein level (HR 1.34 [1.03–1.73]), elevated white blood cell count (HR 1.32 [1.03–1.69]), and the number of involved arteries ≥6 (HR 1.31 [1.00–1.72]) at baseline independently increased the risk of relapse and were included in the prediction model. The C-index of the prediction model was 0.70 (95% CI 0.67–0.74). Predictions correlated with observed outcomes on the calibration plots. Compared to the low-risk group, both medium and high-risk groups had a significantly higher relapse risk. Disease relapse is common in TAK patients. This prediction model may help to identify high-risk patients for relapse and assist clinical decision-making. [Display omitted] [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09536205
- Volume :
- 111
- Database :
- Academic Search Index
- Journal :
- European Journal of Internal Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 163228666
- Full Text :
- https://doi.org/10.1016/j.ejim.2023.02.027