Back to Search
Start Over
Skin microbiome and its association with host cofactors in determining atopic dermatitis severity.
- Source :
-
Journal of the European Academy of Dermatology & Venereology . Apr2023, Vol. 37 Issue 4, p772-782. 11p. - Publication Year :
- 2023
-
Abstract
- Background: Atopic dermatitis (AD) is a heterogeneous, chronic inflammatory skin disease linked to skin microbiome dysbiosis with reduced bacterial diversity and el)evated relative abundance of Staphylococcus aureus (S. aureus). Objectives: We aimed to characterize the yet incompletely understood association between the skin microbiome and patients' demographic and clinical cofactors in relation to AD severity. Methods: The skin microbiome in 48 adult moderate-to-severe AD patients was investigated using next-generation deep sequencing (16S rRNA gene, V1–V3 re)gion) followed by denoising (DADA2) to obtain amplicon sequence variant (ASV) composition. Results: In lesional skin, AD severity was associated with S. aureus relative abun)dance (rS = 0.53, p<0.001) and slightly better with the microbiome diversity measure Evenness (rS = −0.58, p<0.001), but not with Richness. Multiple regression confirmed the association of AD severity with microbiome diversity, including Shannon (in le)sional skin, p<0.001), Evenness (in non-lesional skin, p = 0.015) or S. aureus relative abundance (p<0.012), and with patient's IgE levels (p<0.001), race (p<0.032), age (p<0.034) and sex (p = 0.012). The lesional model explained 62% of the variation in AD severity, and the non-lesional model 50% of the variation. Conclusions: Our results specify the frequently reported “reduced diversity” of the AD-related skin microbiome to reduced Evenness, which was in turn mainly driven by S. aureus relative abundance, rather than to a reduced microbiome Richness. Finding associations between AD severity, the skin microbiome and patient's cofac)tors is a key aspect in developing new personalized AD treatments, particularly those targeting the AD microbiome. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ATOPIC dermatitis
*BACTERIAL diversity
*RACE
*STAPHYLOCOCCUS aureus
*SKIN diseases
Subjects
Details
- Language :
- English
- ISSN :
- 09269959
- Volume :
- 37
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of the European Academy of Dermatology & Venereology
- Publication Type :
- Academic Journal
- Accession number :
- 163238013
- Full Text :
- https://doi.org/10.1111/jdv.18776