甲醛次硫酸氢钠二水合物促进的醌芳基化反应.

The arylation reaction of benzoquinone using aryl iodides as the arylating reagent and rongalite (hydroxymethanesulfinic acid monosodium salt dihydrate) as the super electron donor has been developed under mild conditions. The reaction conditions are optimized using 4-iodonitrobenzene and benzoquinone as the model substrates. The effects of base, solvent, reaction temperature and substrate ratio on the reaction are investigated. Results show that the optimum reaction condition is as follows: 4-iodonitrobenzene (0. 2 mmol), benzoquinone (1 mmol), rongalite (0. 4 mmol), potassium hydroxide (0. 6 mmol), DMSO (1 mL), nitrogen atmosphere, 80 ℃ 24 h. Under this condition, the yield of the target product could reach up to 82%. Other aryl iodides and quinones also show good compatibilities, affording the corresponding products in 62%~84% yields. [ABSTRACT FROM AUTHOR]