PTABS: A Unique Water-Soluble π-Acceptor Caged Phosphine.

Caged phosphines have unique structures and provide many advantageous properties that can be fine-tuned to develop efficient catalytic systems. Our research group recently introduced a highly water-soluble caged phosphine: PTABS (KapdiPhos), which is a derivatized form of triazaphosphaadamantane, and explored its applicability as a strongly π-accepting ligand in combination with metals such as Pd or Cu in a variety of cross-coupling reactions of biologically relevant halonucleosides as well as chloroheteroarenes. This account details our journey from ideation to the various catalytic applications of the ligands and eventually to its commercialization. 1 Introduction 2 Derivatization of PTA to PTABS and Its Applications 2.1 Nucleoside Modification 2.2 Heteroarene Modification 3 Conclusion 4 Summary and Future Outlook [ABSTRACT FROM AUTHOR]