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CRISPR/Cas-Based MicroRNA Biosensors.

Authors :
Qian Zhang
Xinyi Zhang
Xiaoran Zou
Fei Ma
Chun-Yang Zhang
Source :
Chemistry - A European Journal. 3/16/2023, Vol. 29 Issue 16, p1-16. 16p.
Publication Year :
2023

Abstract

As important post-transcriptional regulators, microRNAs (miRNAs) play irreplaceable roles in diverse cellular functions. Dysregulated miRNA expression is implicated in various diseases including cancers, and thus miRNAs have become the valuable biomarkers for disease monitoring. Recently, clustered regularly interspaced short palindromic repeats/CRISPR-associated (CRISPR/Cas) system has shown great promise for the development of next-generation biosensors because of its precise localization capability, good fidelity, and high cleavage activity. Herein, we review recent advance in development of CRISPR/Cas-based biosensors for miRNA detection. We summarize the principles, features, and performance of these miRNA biosensors, and further highlight the remaining challenges and future directions. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09476539
Volume :
29
Issue :
16
Database :
Academic Search Index
Journal :
Chemistry - A European Journal
Publication Type :
Academic Journal
Accession number :
163329367
Full Text :
https://doi.org/10.1002/chem.202203412