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Euryachincoside, a Novel Phenolic Glycoside with Anti-Hepatic Fibrosis Activity from Eurya chinensis.
- Source :
-
Planta Medica . Apr2023, Vol. 89 Issue 5, p516-525. 10p. - Publication Year :
- 2023
-
Abstract
- Eurya chinensis has been recorded as a folk medicine traditionally used for treatment of a variety of symptoms. However, the phytochemical and pharmacological investigations of this plant are still scarce. A novel phenolic glycoside named Euryachincoside (ECS) was isolated by chromatographic separation from E. chinensis, and its chemical structure was identified by analysis of HRMS and NMR data. Its anti-hepatic fibrosis effects were evaluated in both HSC-T6 (rat hepatic stellate cells) and carbon tetrachloride (CCl4)-induced mice with Silybin (SLB) as the positive control. In an in vitro study, ECS showed little cytotoxicity and inhibited transforming growth factor-beta (TGF- β)-induced Collagen I (Col1) along with alpha-smooth muscle actin (α -SMA) expressions in HSC-T6. An in vivo study suggested ECS significantly ameliorated hepatic injury, secretions of inflammatory cytokines, and collagen depositions. Moreover, ECS markedly mediated Smad2/3, nuclear factor kappa B (NF- κ B) and nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways both in vitro and vivo. These present findings confirmed that ECS is a novel phenolic glycoside from E. chinensis with promising curative effects on hepatic fibrosis, and its mechanisms may include decreasing extracellular matrix accumulation, reducing inflammation and attenuating free radicals via Smad2/3, NF- κ B and Nrf2 signaling pathways, which may shed light on the exploration of more effective phenolic glycoside-based anti-fibrotic agents. [ABSTRACT FROM AUTHOR]
- Subjects :
- *IN vitro studies
*TRANSFORMING growth factors-beta
*CYTOKINES
*COLLAGEN
*IN vivo studies
*ANIMAL experimentation
*NUCLEAR factor E2 related factor
*GLYCOSIDES
*FIBROSIS
*NUCLEAR magnetic resonance spectroscopy
*NF-kappa B
*TRADITIONAL medicine
*CELLULAR signal transduction
*TREATMENT effectiveness
*RESEARCH funding
*PLANT extracts
*CELL surface antigens
*MICE
*IMMUNODIAGNOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 00320943
- Volume :
- 89
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Planta Medica
- Publication Type :
- Periodical
- Accession number :
- 163330763
- Full Text :
- https://doi.org/10.1055/a-1828-2671