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Prenylated flavins: structures and mechanisms.
- Source :
-
FEBS Journal . May2023, Vol. 290 Issue 9, p2232-2245. 14p. - Publication Year :
- 2023
-
Abstract
- The UbiX/UbiD system is widespread in microbes and responsible for the reversible decarboxylation of unsaturated carboxylic acids. The UbiD enzyme catalyzes this unusual reaction using a prenylated flavin (prFMN) as cofactor, the latter formed by the flavin prenyltransferase UbiX. A detailed picture of the biochemistry of flavin prenylation, oxidative maturation, and covalent catalysis underpinning reversible decarboxylation is emerging. This reveals the prFMN cofactor can undergo a wide range of transformations, complemented by considerable UbiD‐variability. These provide a blueprint for biotechnological applications aimed at producing hydrocarbons or aromatic C–H activation through carboxylation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1742464X
- Volume :
- 290
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- FEBS Journal
- Publication Type :
- Academic Journal
- Accession number :
- 163487424
- Full Text :
- https://doi.org/10.1111/febs.16371