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Inhibition of ferroptosis through regulating neuronal calcium homeostasis: An emerging therapeutic target for Alzheimer's disease.
- Source :
-
Ageing Research Reviews . Jun2023, Vol. 87, pN.PAG-N.PAG. 1p. - Publication Year :
- 2023
-
Abstract
- Alzheimer's disease (AD), a chronic and progressive neurodegenerative disease, generates a serious threat to the health of the elderly. The AD brain is microscopically characterized by amyloid plaques and neurofibrillary tangles. There are still no effective therapeutic drugs to restrain the progression of AD though much attention has been paid to exploit AD treatments. Ferroptosis, a type of programmed cell death, has been reported to promote the pathological occurrence and development of AD, and inhibition of neuronal ferroptosis can effectively improve the cognitive impairment of AD. Studies have shown that calcium (Ca2+) dyshomeostasis is closely related to the pathology of AD, and can drive the occurrence of ferroptosis through several pathways, such as interacting with iron, and regulating the crosstalk between endoplasmic reticulum (ER) and mitochondria. This paper mainly reviews the roles of ferroptosis and Ca2+ in the pathology of AD, and highlights that restraining ferroptosis through maintaining the homeostasis of Ca2+ may be an innovative target for the treatment of AD. [Display omitted] • Ferroptosis promotes the pathological occurrence and development of AD. • Calcium dyshomeostasis is closely related to the pathology of AD. • The calcium–iron interplay is crucial for the occurrence of neuronal ferroptosis. • Calcium dysregulation drives ferroptosis through heightening the crosstalk between endoplasmic reticulum and mitochondria. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15681637
- Volume :
- 87
- Database :
- Academic Search Index
- Journal :
- Ageing Research Reviews
- Publication Type :
- Academic Journal
- Accession number :
- 163551450
- Full Text :
- https://doi.org/10.1016/j.arr.2023.101899